Background: Surgery and anesthesia are safer nowadays than ever before, thanks to persevering with advances in science. But this doesn’t suggest there is zero risk. In fact, surgical treatment and anesthesia are inherently dangerous, and as with any medicine or procedure, there is constantly the chance that something can go wrong. Certain patients are greater probably to experience problems or issues and perchance even death than others due to the fact of their age, clinical conditions, or the kind of surgical treatment they’re having. If you’re planning to have surgery, there are approaches to decrease your risk, including meeting with your anesthesiologist. Objectives: The aim of this study is to assess the Evaluation of risk factors in the post-anesthesia care unit of a tertiary care hospital. Methods: This is an observational study. The study used to be carried out in the admitted patient’s department of anesthesiology, Monno Medical College and Hospital, Manikgonj, Bangladesh. The duration of the study period from July 2020 to June 2021. Results: This study shows that the according to age of 110 Patients aged 10 to 60 years. Here according to Age distribution, 11(10.0%) were <10, 5(4.54%) were 11 20, 21(19.09%) were 21-30, 22(20.0%) were 31-40, 37(33.64%) were 41-50, 8(7.27%) were 51- 60 and 6(5.45%) were >60. And according to gender 57(51.82%) were Male, 53(48.18%) were Female. Conclusions: Perioperative cardiovascular and respiratory damaging activities are the principal motives for extended remain in Post anesthesia care unit. Post anesthesia care unit as triggering elements for problems in the instant postoperative period: hypothermia, hypoxemia, pulmonary edema; apnea, tremors, nausea and vomiting; urinary retention, modifications in coronary heart rhythm.