Malaria and typhoid fever are major aetiological considerations in both acute and prolonged fever of unknown origin (PUO) in the tropics and sub-tropics where opportunities for transmission are wide-ranging. Because of the high prevalence of malaria and typhoid fever in Nigeria, co-infections are common. A cross-sectional study was conducted to determine the prevalence of malaria and typhoid fever co-infection among patient attending Murtala Muhammad Specialist Hospital, Kano. Structural questionnaire were administered to obtain socio – demographic data. A random sampling was done and the estimated sample size is 110, which involved both male and female. Two ml of venous blood sample was collected for malaria and typhoid test. Conventional Widal tests for the detection of Salmonella spp were done as well as blood film preparation for detection of Plasmodium spp. The study show high overall prevalence of malaria 67(60.9%) and typhoid 74(67.3%), the co-infection prevalence 60(54.5%) was equally high. Co-infection rate in females 33(60.0%) was higher (p<0.05) than males 27(49.1%). The non-educated patients had the highest co-infection rate of 30(78.9%). The co-infection rate is higher (p<0.05) among the poor subjects 47(61.8%) than rich participants 13(38.2%). Of the total number of patients age ranging from 1–15 had the highest malaria prevalence of 22 (73.3%) while 61–75 has the least malaria prevalence of 4 (44.4%). On the other hand age ranging from 16–30 had the highest typhoid prevalence of 30 (73.1%) while age range from 61–75 had the least typhoid prevalence of 4(44.4%) (p<0.05). Therefore, there is need to step up sensitization on malaria and typhoid prevention. Other diagnostic tests such as molecular techniques and blood culture should be employed to determine the sensitivity and specificity of Widal and microscopy methods.