Allergic reactions to acrylic denture materials are uncommon yet clinically significant complications in prosthodontics. These reactions primarily result from residual methyl methacrylate monomers and other additives leaching from inadequately polymerized denture base resins. The clinical manifestations include burning sensations, mucosal erythema, and stomatitis. Diagnosis relies on a detailed patient history, clinical examination, and patch testing with dental allergen panels. Management strategies involve denture modification through extended water immersion, alternative material selection, and complete prosthesis replacement. Understanding the pathophysiology, diagnostic approach, and treatment options enables clinicians to provide effective care to affected patients.